Mixing of low-dose cohesive drug and overcoming of pre-blending step using a new gentle-wing high-shear mixer granulator

The objective of this study was to examine the influence of drug amount and mixing time on the homogeneity and content uniformity of a low-dose drug formulation during the dry mixing step using a new gentle-wing high-shear mixer. Moreover, the study investigated the influence of drug incorporation mode on the content uniformity of tablets manufactured by different methods. Albuterol sulfate was selected as a model drug and was blended with the other excipients at two different levels, 1% w/w and 5% w/w at impeller speed of 300?rpm and chopper speed of 3000?rpm for 30?min. Utilizing a 1?ml unit side-sampling thief probe, triplicate samples were taken from nine different positions in the mixer bowl at selected time points. Two methods were used for manufacturing of tablets, direct compression and wet granulation. The produced tablets were sampled at the beginning, middle, and end of the compression cycle. An analysis of variance analysis indicated the significant effect (p?相似文献   

Homogeneous non-equilibrium two-phase choked flow modeling

The estimation of the release conditions is critical input to subsequent risk assessment accident analysis. To this respect a new homogeneous non-equilibrium two-phase model is proposed to simulate the depressurization from stagnation conditions leading to the bubbly flow regime. The proposed model, being intermediate between HEM (homogeneous equilibrium) and HFM (homogeneous frozen) models, presents no discontinuity in the liquid phase depressurization path gradient and therefore no discontinuity in sound speed. The proposed model is successfully validated against the NASA hydrogen critical flow experiments and compared against predictions from both HEM and HFM, using hydrogen physical properties from NIST. An increase of the pressure difference between stagnation and the intersection of isentropic with saturation line leads to increase of the choked mass flux, decrease of the throat to stagnation pressure ratio, decrease of the liquid superheat and decrease of the vapor quality. The proposed model was found to overestimate the experimental throat mass fluxes by no more than 10% and underestimate the experimental throat to stagnation pressure ratios by no more than 50%, while predicted liquid superheat values range from 3.8 to 11% of the saturation temperature. Deviations between models were found to increase for low values of the pressure difference parameter, where non-equilibrium effects become more important. Under these conditions the throat mass flux is underestimated by maximum 20% by HEM and overestimated up to 32% by HFM, while the throat to stagnation pressure ratio is overestimated by up to 72% and underestimated by 80% respectively.     

A new ship energy management algorithm to the smart electricity grid system

In this paper, a new energy management algorithm has been suggested for the ships connected with alternative energies considering the smart electricity grid features. The algorithm focuses on the use of optimum energy source on the shipboard based on the priorities of authorities such as the most economic, environmental, or both criteria at the ports. The algorithm is performed in MATLAB, and several case studies are simulated to validate the results. The 5 maritime nations, which are at different regions: United States, Belgium, Turkey, China, and Australia, are taken into account in the case studies. The actual data of a bulk carrier ship have been used to achieve tangible results in the simulations. The results of the case studies are compared to determine the changes of energy cost and released emission to meet demand of electricity on the ships. Capital cost of the proposed concept is also given to make an economic evaluation. The results show that the ship energy management algorithm provides the significant economic and environmental advantages. This paper aims to contribute to the importance of the ships in the smart electricity grid concept for the maritime and electricity sector representatives.     

Effect of paddy variety,milling status and aeration on the progeny emergence of Sitophilus oryzae L. (Coleoptera: Curculionidae)

In Sri Lanka, insects cause enormous losses in stored paddy; the rice weevil Sitophilus oryzae is a devastating insect. The magnitude of losses in stored paddy caused by insects varies with characteristics of paddy but has not yet been fully investigated. Due to the increased concerns on the use of synthetic chemicals, safer alternative pest management strategies for stored paddy are needed. Objectives of this study were to determine the effect of paddy variety, milling status and nature of aeration on the progeny emergence of S. oryzae. The experimental design was a three-factor factorial, completely randomized design (CRD).Freshly emerged S. oryzae adults were introduced to un-milled paddy or milled/polished rice belonging to traditional and improved varieties. The samples were maintained either open or airtight, and the progeny adults emerged was determined at monthly intervals. Progeny emergence was lower in the traditional varieties, un-milled paddy and under air-tight condition compared to improved varieties, milled/polished rice and aerated samples, respectively. Overall, the improved variety Bg 300 exhibited the maximum resistance to infestation by S. oryzae. Furthermore, white-colour and long-grain varieties produced lower progeny of S. oryzae than red-colour and short-grain varieties, respectively. It is concluded that the maximum protection in paddy/rice from insect infestation during storage can be achieved by using traditional varieties, stored as un-milled paddy (without dehusked) under airtight condition.     

Metabonomics analysis of nonvolatile small molecules of beers during forced ageing

Three kinds of beers with different degrees of ageing were used to examine their nonvolatile small molecules by a metabonomics approach based on ultra performance liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry (UPLC‐Q‐ToF‐MS/MS). Results showed that a total of 2114 compounds were detected in forced‐aged beers with the positive mode of UPLC‐Q‐ToF‐MS/MS. There was a clear separation among three groups of beers with different degrees of ageing in principal component analysis (PCA) model. Sixteen potential metabolite markers related to beer oxidative stability were identified by orthogonal partial least‐squares discriminate analysis (OPLS‐DA). Results from the changes in the spectrum also indicated that some new compounds formed in beer during forced ageing. Thus, the proposed metabonomics approach is a powerful tool to give a fully understanding the ageing process of beer based on the identification of the markers related to oxidative stability.     

Age and productivity as determinants of firm survival over the industry life cycle

This paper contributes to fill the gap between the literature on the determinants of firm survival and the empirical works on the industry life cycle (ILC). Using a representative sample of Spanish firms with 10 or more employees over the period 1993–2009, the role played by firm age and productivity in firm survival is empirically analysed across three stages of the life cycle of forty-seven 3-digit manufacturing sectors. In the ‘early’ stage of the ILC, firm age is negatively correlated with hazard rates while firm productivity is not. Firm productivity is associated with lower hazard in the ‘mature’ stage of the ILC, when competition is primarily efficiency-driven, while firm age does not play a significant role for firm survival. In the ‘intermediate’ stage, both age and productivity play a role in reducing firms’ hazard rates.     

节理峰前剪切刚度软化模型及其影响因素分析

节理峰前剪切应力-位移曲线是研究节理剪切行为的重要内容。然而目前对于节理峰前剪切行为大多以线性描述,不能较好的描述非线性的特点。对于非线性的描述也仅仅是唯象描述剪切应力-位移曲线,未能反映影响模型的参数物理意义及影响因素。以峰前节理刚度软化行为为出发点,采用归一化的思想将节理剪切刚度与位移无量纲化,用双曲线函数表示出剪切刚度与位移之间的关系。提出了考虑刚度软化的峰前剪切本构关系,通过与试验结果对比验证了本构关系的合理性。影响该模型最重要的两个因素是初始剪切刚度与峰值剪切位移。以Greenwood和Williamson模型为基础在细观上探讨了初始剪切刚度的影响因素;抓住法向应力与节理粗糙度主要因素,探讨了影响峰值剪切位移的影响因素。对模型参数的研究有助于进一步阐明节理峰前剪切机理。